Publications
Laser-assisted epicutaneous immunization to target human skin dendritic cells
Christoph H. Tripp, Hermann Voit, Angela An, Magdalene Seidl-Philipp, Johanna Krapf, Stephan Sigl, Nikolaus Romani, Barbara Del Frari, Patrizia Stoitzner
Experimental Dermatology, April 02, 2021
https://doi.org/10.1111/exd.14346
Laser-facilitated epicutaneous immunization with SARS-CoV-2 spike protein induces ACE2 blocking antibodies in mice
Sandra Scheiblhofer, Stephan Drothler, Werner Braun, Reinhard Braun, Maximilian Boesch, Richard Weiss
bioRxiv preprint. February 22, 2021
https://doi.org/10.1101/2021.02.22.432259
Laser irradiation of ocular tissues to enhance drug delivery
Raghu Raj Singh Thakur, Samer Adwan, Ismaiel Tekko, Karim Soliman, Ryan F. Donnelly
Int. Journal of Pharmaceutics. 2021 March; Volume 596, 120282
doi: 10.1016/j.ijpharm.2021.120282
Laser-facilitated epicutaneous immunotherapy with hypoallergenic beta-glucan neoglycoconjugates suppresses lung inflammation and avoids local side effects in mouse model of allergic asthma
Evgeniia Korotchenko, Viktoria Schießl, Sandra Scheiblhofer, Mario Schubert, Elfriede Dall, Isabella A. Joubert, Helen Strandt, Theresa Neuper, Muamera Sarajilic, Renate Bauer, Mark Geppert, David Joedicke, Sabrina Wildner, Susanne Schaller, Stephan Winkler, Gabriele Gadermaier, Jutta Horejs-Hoeck, Richard Weiss
Allergy. 2021 Jan;76(1):210-222
doi: 10.1111/all.14481
Laser-facilitated epicutaneous immunotherapy with depigmented house dust mite extract alleviates allergic responses in a mouse model of allergic lung inflammation
Evgeniia Korotchenko, Raquel Moya, Sandra Scheiblhofer, Isabella A. Joubert, Jutta Horejs-Hoeck, Michael Hauser, David Calzada, Victor Iraola, Jerónimo Carnés, Richard Weiss
Allergy. 2020 May;75(5):1217-1228
doi: 10.1111/all.14164
Dual function of Langerhans cells in skin TSLP-promoted Tfh cell differentiation in mouse atopic dermatitis
Pierre Marschall, Ruicheng Wei, Justine Segaud, Wenjin Yao, Pierre Hener, Beatriz Falcon German, Pierre Meyer, Cecile Hugel, Grace Ada Da Silva, Reinhard Braun, Daniel H Kaplan, Mei Li
J Allergy Clin Immunol, 2020 Oct 14; S0091-6749(20)31408-1
doi: 10.1016/j.jaci.2020.10.006
Safety and immunogenicity of the epicutaneous reactivation of pertussis toxin immunity in healthy adults: a phase I, randomized, double-blind, placebo-controlled trial
Chatzis O, Blanchard-Rohner G, Mondoulet L, Pelletier B, De Gea-Hominal A, Roux M, Huttner A, Hervé P.L., Rohr M, Matthey A, Gutknecht G, Lemaître B, Hayem C, Pham H.T., Wijagkanalen W, Lambert P.H., Benhamou P.H., Siegrist C.A.
Clinical Microbiology and Infection, Sept 05, 2020
doi: 10.1016/j.cmi.2020.08.033
Targeted cutaneous delivery of etanercept using Er:YAG fractional laser ablation
del Río Sancho S, Lapteva M, Sonaje K, Böhler C, Ling V, Boehncke W, Kalia Y
International Journal of Pharmaceutics, Volume 580, 30 April 2020
doi: 10.1016/j.ijpharm.2020.119234
Epidermal micro-perforation potentiates the efficacy of epicutaneous vaccination
Hervé P, Dhelft V, Plaquet C, Rosseaux A, Bouzereau A, Gaulme L, Tilleul S, Ligouis M, Donne N, Lambert P, Hong-Thai P, Wijagkanalan W, Sampson H A, Mondoulet L
Journal of Controlled Release, Volume 298, 28 March 2019, Pages 12-26
doi: 10.1016/j.jconrel.2019.02.004
Fractional laser ablation for the targeted cutaneous delivery of an anti-CD29 monoclonal antibody - OS2966
Lapteva M, del Río Sancho S, Wu E, Carbonell WS, Böhler C, Kalia YN
Sci Rep. 2019 Jan 31; 9(1):1030. doi: 10.1038/s41598-018-36966-0
Parameters in fractional laser assisted delivery of topical anesthetics: Role of laser type and laser settings.
Meesters AA, Nieboer MJ, Kezic S, de Rie MA, Wolkerstorfer A
Lasers Surg Med, 2018 May 7; doi: 10.1002/lsm.22936
Lack of dermal penetration of topically applied gentamicin as pharmacokinetic evidence indicating insufficient efficacy.
Oesterreicher Z, Lackner E, Jäger W, Höferl M, Zeitlinger M
J Antimicrob Chemother, 2018 Aug 2; doi: 10.1093/jac/dky274
Needle-free cutaneous delivery of living human cells by Er:YAG fractional laser ablation.
Yu J, Dubey S, Kalia YN
Expert Opin Drug Deliv. 2018 Jun;15(6):559-566. doi: 10.1080/17425247.2018.1472570
Application of water-soluble polyvinyl alcohol-based film patches on laser microporated skin facilitates intradermal macromolecule and nanoparticle delivery.
Engelke L, Winter G, Engert J
Eur J Pharm Biopharm, 2018 Juli;128:119-130. doi: 10.1016/j.ejpb.2018.04.008
Delivery of Methotrexate and Characterization of Skin Treated by Fabricated PLGA Microneedles and Fractional Ablative Laser.
Nguyen HX, Banga AK
Pharm Res, 2018 Feb, 21;35(3):68. doi: 10.1007/s11095-2369-6
Qualitative and quantitative analysis of lateral diffusion of drugs in human skin.
Nguyen HX, Puri A, Bhattaccharjee SA, Banga AK
Int J Pharm, 2018 Jun 10; 544(1):62-74, doi: 10.1016/j.ijpharm.2018.04.013
Transdermal delivery of human growth hormone via laser-generated micropores.
Yang Song, Karishma Hemmady, Ashana Puri, Ajay K. Banga
Drug Deliv Transl Res., 2018 Apr; 8(2):450-460, doi: 10.1007/s13346-017-0370-y
Synergistic effects of dendritic cell targeting and laser-microporation on enhancing epicutaneous skin vaccination efficacy.
Machado Y, Duinkerken S, Hoepflinger V, Mayr M, Korotchenko E, Kurtaj A, Pablos I, Steiner M, Stoecklinger A, Lübbers J, Schmid M, Ritter U, Scheiblhofer S, Ablinger M, Wally V, Hochmann S, Raninger AM, Strunk D, van Kooyk Y, Thalhamer J, Weiss R
J Control Release, 2017 Sep 14; 266:87-99, doi: 10.1016/j.conrel.2017.09.020
Skin vaccination via fractional infrared laser ablation - Optimization of laser-parameters and adjuvantation
S Scheiblhofer, A Strobl, V Hoepflinger, T Thalhamer, M Steiner, J Thalhamer, R Weiss
Vaccine, Jan. 2017, pii: S0264-410X(17)30058-0, DOI:10.1016/j.vaccine.2016.11.105, PMID: 28117172
Potential of nanoparticles for allergen-specific immunotherapy - use of silica nanoparticles as vaccination platform
S Scheiblhofer, Y Machado, A Feinle, J Thalhamer, N Hüsing, R Weiss
Expert Opinion on Drug Delivery, Dec. 2016, 13(12):1777-1788, DOI:10.1080/17425247.2016.1203898, PMID: 27321476
Laser-facilitated epicutaneous immunotherapy to IgE-mediated allergy
MN Kumar, C Zhou, MX Wu
Journal of Controlled Release, Aug. 2016, 235:82-90, DOI:10.1016/j.conrel.2016.05.057, PMID: 27235977
Fractional Laser Ablation for the Cutaneous Delivery of Triamcinolone Acetonide from Cryomilled Polymeric Microparticles: Creating Intraepidermal Drug Depots
M Singhal, S Del Rio-Sancho, K Sonaje, YN Kalia
Mol Pharm, Feb. 2016;13(2):500-11, DOI:10.1021/acs.molpharmaceut.5b00711, PMID: 26731121
Ablative fractional laser enhances MAL-induced PpIX accumulation: Impact of laser channel density, incubation time and drug concentration
C.S. Haak, K. Christiansen, A.M. Erlendsson, E.H. Taudorf, D. Thaysen-Petersen, H.C. Wulf, M. Haedersdal
Journal of Photochemistry & Photobiology, B: Biology, June 2016, 159:42-8, DOI:10.1016/j.iphotobiol.2016.03.021
Practical approach to the use of daylight photodynamic therapy with topical methyl aminolevulinate for actinic keratosis: a European consensus
Morton CA, Wulf HC, Szeimies RM, Gilaberte Y, Basset-Sequin N, Sotiriou E, Piaseriao S, Hunger RE, Baharlou S, Sidoroff A, Braathen LR
J Eur Acad Dermatol Venerol, Sept. 2015;29(9):1718-23, DOI:10.1111/jdv.12974, PMID: 25627399
Ablative fractional laser alters biodistribution of ingenol mebutate in the skin
A.M. Erlendsson, E.H. Taudorf, A.H. Eriksson, C.S. Haak, J.R. Zibert, U. Paasch, R.R. Anderson, M. Haedersdal
Arch Dermatol Res, Aug. 2015,;307(6):515:-22, DOI:10.1007/s00403-015-1561, PMID:25832754
Laser-Assisted Intradermal Delivery of Adjuvant-Free Vaccines Targeting XCR1+ Denditric Cells Induces Potent Antitumoral Responses
D. Terhorst, E. Fossum, A Baranska, S. Tamoutounour, C. Malosse, M. Garbani, R. Braun, E. Lechat, R. Crameri, B. Bogen, S. Henri, B. Malissen
The Journal of Immunology, May 2015, DOI:10.4049/jimmunol.1500564
Combination of ablative fractional laser and daylight-mediated photodynamic therapy for actinic keratosis in organ transplant recipients - a randomized controlled trial
K. Togsverd-Bo, U. Lei, A.M. Erlendsson, E.H. Taudorf, P.A. Philipsen, H.C. Wulf, L. Skov and M. Haedersdal
British Journal of Dermatology, Feb. 2015, DOI:10.1111/bjd.13222, PMID: 24975199
The origins and functions of dendritic cells and macrophages in the skin
B Malissen, S Tamoutounour, S Henri
Nat Rev Immunol, June 2014;14(6):417-28, DOI:10.1038/nri3683, PMID: 24854591
Next generation intra- and transdermal therapeutic systems: Using non- and minimally-invasive technologies to increase drug delivery into and across the skin
T Gratieri, I Alberti, M Lapteva, YN Kalia
European Journal of Pharmaceuticical Sciences, Dec. 2013; 50(5):609-22, DOI:10.1016/j.ejps.2013.03.019, PMID: 23567467
Controlled intra- and transdermal protein delivery using a minimally invasive Erbium:YAG fractional laser ablation technology
YG Bachhav, A Heinrich, YN Kalia
European Journal of Pharmaceutics and Biopharmaceutics, June 2013; 84(2):355-64, DOI:10.1016/j.ejpb.201211.018, PMID: 23207321
Laser microporation of the skin: prospects for painless application of protective and therapeutic vaccines
S Scheiblhofer, J Thalhamer, R Weiss
Expert Opinion Drug Delivery, June 2013; 10(6):761-73, DOI:10.1517/17425247.2013.773970, PMID: 23425032
Transcutaneous immunotherapy via laser-generated micropores efficiently alleviates allergic asthma in Phl p 5-sensitized mice
D. Bach, R. Weiss, M. Hessenberger, S. Kitzmueller, E.E. Weinberger, W.D. Krautgartner, C. Hauser-Kronberger, C. Boehler, J. Thalhamer, S. Scheiblhofer
European Journal of Allergy and Clinical Immunology, Nov 2012; 67(11): 1365-1374, DOI: 10.1111/all.12005
Transcutaneous vaccination via laser microporation
R. Weiss, M. Hessenberger, S. Kitzmueller, D. Bach, E.E. Weinberger, W.D. Krautgartner, C. Hauser-Kronberger, B. Malissen, C. Boehler, Y.N. Kalia, J.Thalhamer, S. Scheiblhofer
J Control Release 2012. September 2012; 162(2): 391-399
Erbium:YAG fractional laser ablation for the percutaneous delivery of intact functional therapeutic antibodies
J Yu, DR Kalaria, YN Kalia
J Control Release, Nov. 2011; 156(1):53-9, DOI: 10.1016/j.conrel.2011.04.024, PMID: 21803083
Using laser microporation to improve transdermal delivery of diclofenac: Increasing bioavailability and the range of therapeutic applications.
Bachhav YG, Heinrich A, Kalia YN.
Eur J Pharm Biopharm. 2011 Aug; 78(3):408-14. Epub 2011 Mar 21.
PMID: 21397689
High power, diode side pumped Er:YAG lasers
Heinrich A, Bragagna T.
Lasers and Electro-Optics Europe (CLEO EUROPE/EQEC), 2011 Conference and 12th European Quantum Electronics Conference
Issue Date: 22-26 May 2011
On page(s): 1 - 1
Location: Munich
ISSN: Pending
Print ISBN: 978-1-4577-0533-5
INSPEC Accession Number: 12189945
Digital Object Identifier: 10.1109/CLEOE.2011.5942493
Date of Current Version: 07 Juli 2011
Using controlled laser-microporation to increase transdermal delivery of prednisone.
Yu J, Bachhav YG, Summer S, Heinrich A, Bragagna T, Boehler C, Kalia YN.
J Control Release. 2010 Nov 20; 148(1):e71-3. No abstract available.
PMID: 21529638
Effect of controlled laser microporation on drug transport kinetics into and across the skin.
Bachhav YG, Summer S, Heinrich A, Bragagna T, Boehler C, Kalia YN.
J Control Release. 2010 Aug 17; 146(1):31-6. Epub 2010 May 25.
PMID: 20678988
Noninvasive Transdermal Iontophoretic Delivery of Biologically Active Human Basic Fibroblast Growth Factor
S. Dubey, R. Perozzo, L. Scapozza, YN Kalia
Molecular Pharmaceutics Aug. 2011; 8(4):1322-31, DOI: 10.1021/mp200125j, PMID: 21696184
Development and validation of an analytical method for the quantification of cytochrome c in skin transport studies
YG. Bachhav, YN. Kalia
Biomedical Chromatography, July 2010, 24(7):732-6, DOI:10.1002/bmc 1356
Mid-infrared Q-switched Er:YAG laser for medical applications
Skorczakowski M, Swiderski J, Pichola W, Nyga P, Zajac A, Maciejewska M, Galecki L, Kasprzak J, Gross S, Heinrich A, Bragagna T.
Publication date: 2010.01.07
Laser Physics Letters
DOI: 10.1002/lapl.201010019
